Projects

Current research projects

Leishmania population genomics: Our focus us to understand Leishmania populations, the genetic factors that influence drug treatments and clinical outcomes. We use population, quantitative and evolutionary genomics in collaboration with clinicians, immunologists and epidemiologists.

Population & quantitative genetics of Leishmania infantum in Brazil
As part of the UK:Brazil Joint Centre Partnership in leishmaniasis we are using population genomics and quantitative genetic methods to understand various aspects of Leishmania infantum in Brazil.
Funders: Wellcome Trust, GCRF, MRC and FAPESP.
Collaborators: Jeremy Mottram (York), Carlos Henrique Nery Costa (Brazil), Elisa Cupolillo (Brazil)

Immstat/GWAS: Population genomics of Leishmania donovani in East Africa
Recent MRC funding will describe the diversity of Leishmania donovani in Ethiopia, Uganda, Kenya and Sudan.
Funder: MRC
Collaborators: Paul Kaye (York), Asrat Hailu (Ethiopia), Joseph Olobo (Uganda), Ahmed Musa (Sudan),  Margaret Mbuchi (Kenya), Jane Mbui (Kenya).

Genomics of the extremophile red alga Galdieria sulphuraria
With Seth Davis, we are investigating the weird and wonderful genome of Galdieria sulphuraria.
Funder: BBSRC

Population genomics of plant pathogen Ralstonia solanacearum
With Ville Friman, we are applying population genomics to understand how R. solanacearum spreads through waterways in the UK and causes brown rot in potatoes.
Funder: BBSRC and NERC.
Collaborator: Ville Friman